With SharePoint 2013, the time required to enable Extradium on a web application has significantly increased. As a result, the Extradium enablement process can last longer than the 110 seconds default ASP.NET time out.
In order to remediate the issue, please open the web.config of the SharePoint Central Administration site and locate the <httpRuntime> section.
Add an executionTimeout attribute and set it to a value significantly larger than 110 (the attribute value is in seconds, see http://msdn.microsoft.com/en-us/library/e1f13641(v=vs.100).aspx for details).
Your httpRuntime section should now be similar to the one in the following screenshot:
Save the web.config file and try to enable Extradium on your web application again.